Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
نویسندگان
چکیده
Deborah S. Mortensen, Kimberly E. Fultz, Shuichan Xu, Weiming Xu, Garrick Packard, Godrej Khambatta, James C. Gamez, Jim Leisten, Jingjing Zhao, Julius Apuy, Kamran Ghoreishi, Matt Hickman, Rama Krishna Narla, Rene Bissonette, Samantha Richardson, Sophie X. Peng, Sophie Perrin-Ninkovic, Tam Tran, Tao Shi, Wen Qing Yang, Zeen Tong, Brian E. Cathers, Mehran F. Moghaddam, Stacie S. Canan, Peter Worland, Sabita Sankar and Heather K. Raymon
منابع مشابه
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2) are critical mediators of the PI3K-AKT pathway, which is frequently mutated in many cancers, leading to hyperactivation of mTOR signaling. Although rapamycin analogues, allosteric inhibitors that target only the mTORC1 complex, have shown som...
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